Newcastle University

Pathogenesis, molecular and signalling mechanisms of inflammatory skin disease, skin cancer and ageing.

Cell signalling mechanisms activated by physiological and pathological environmental signals – including ultraviolet radiation, wounding/mechanical stress and genetic mutations

Genetic factors underlying inter-individual cutaneous responses

Clinical, translational and therapeutic research (including pharmacogenetics) of inflammatory skin disease (eg psoriasis and atopic eczema) and skin cancer (eg metastatic melanoma and squamous cell carcimoma) and bio-marker development

1. Skin dendritic cells and cutaneous immunology
2. Stem cell research
3. Approaches and expertise

There is a strong emphasis on inter-disciplinary working and the integration of clinical investigation and basic research as highlighted by a close working relationship between the clinical dermatology and the academic departments, based within the Institute of Cellular Medicine and the Institute of Genetic Medicine and The Newcastle Cancer Centre .    

Encourage imaginative and multidisciplinary approaches and have particular expertise in:

1. translational medicine (in vivo studies, bio-markers, therapeutics)
2. model systems (genetically modified skin equivalents)
3. wound healing
4. stem cell biology
5. imaging (live cell, confocal, high-content, in vivo)
6. UV irradiation (dosimetry, action spectra and human exposure)

Cell signalling and the analysis of cellular, mitochondrial, nuclear responses, flow cytometry, fluorescenec activated cell sorting, functional immunology and next generation sequencing. We foster a vibrant, interactive and collaborative environment as evidenced by multiple joint grants, joint supervision of research students and scientific publications.  The group comprises Principal Investigators (PIs) from Dermatology, Pharmacology, Haematology, Toxicology and Medical Physics within ICM and IGM.  In addition, Principal Investigators have collaborations across other research institutes (eg NUIA, ICAMB, IGM, NESCI, NICR) and research groups (eg Cell Signalling, Nanotechnology).

Our research environment is enhanced by key external collaborations promoting exchange of ideas and expertise.  These include links within and outwith UK/Europe:

• University of Durham
• University of Rome
• Singapore Immunology Network
• University of Oxford
• Queens University, Belfast
• The Hospital for Sick Children, Toronto
• The Institute of Cancer Research, London

Researcher Training

We place a strong emphasis on postgraduate and post-doctoral training and have an active weekly programme both within ICM and dermatology (clinical and basic science journal clubs, research in progress meetings) and play a key role in running the MRes in Medical and Molecular Biosciences. 

Many of our clinical trainees pursue higher research degrees funded through external nationally funded fellowships and our PhD students have secured both prestigious fellowships (European Commission) and post-doctoral positions  (e.g. Khavari lab, Stanford; Buck Institute, San Francisco; NIH, Bethesda; Sydney University, Australia).  In 2006/2007 we were one of only three units in England and Wales to be awarded academic clinical fellowships in dermatology through a national competition and a Walport/NIHR Lectureship was recently established.  Currently, we have two Wellcome intermediate clinical fellows in post, a unique achievement amongst UK dermatology units.

Dermatology is one of six priority areas supported through a Wellcome Clinical Research Training Fellowship Scheme in Translational Medicine and Therapeutics at Newcastle University which provides up to four fellowships per year for the next five years.   This scheme is designed principally to provide training for clinicians in translational research to PhD level in Newcastle.

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